Carbon Dioxide → 2,6-Dichloro-3,5-difluorophenol
反応式
[Cl:1][C:2]1[C:3]([F:14])=[C:4]([C:8]([F:13])=[C:9]([Cl:12])[C:10]=1[OH:11])C(O)=O.CN(C)C=O.C(=O)=O.C1(C)C=CC=CC=1>O>[Cl:1][C:2]1[C:3]([F:14])=[CH:4][C:8]([F:13])=[C:9]([Cl:12])[C:10]=1[OH:11]参加物
6
実験手順
50 g of 3,5-dichloro-2,6-difluoro-4-hydroxy-benzoic acid and 10 ml of dimethylformamide are mixed and heated. At 105°-130° C., carbon dioxide evolves, and the reaction is allowed to proceed to completion at this temperature. 200 ml of toluene and 80 ml of water are then added in succession, the phases are separated, and the organic phase is dried and then distilled. 34 g of the product of a boiling point of 87°-88° C. and refractive index of nD20 : 1.5310 are obtained.
後処理
- temperatureheated
- customAt 105°-130° C.
- customthe phases are separated
- customthe organic phase is dried
- distillationdistilled
出典と根拠
- ORDレコード
- ord-34b8b9b0f5eb429e95851bddf2ba735a
- 出典データセット
- uspto-grants-1991_10
- 特許番号
- US05059623
反応ノート
読み込み中…