Hydrochloric Acid → 2,5-Dichloro-3-fluoro-4-methylbenzoic acid

HRID 34587ノート

反応式

HRID 34587 の反応式
[Cl:1][C:2]1[C:11]([F:12])=[C:10]([CH3:13])[C:9]([Cl:14])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[K+].Cl>CCO>[Cl:1][C:2]1[C:11]([F:12])=[C:10]([CH3:13])[C:9]([Cl:14])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 21298239Methyl 2,5-dichloro-3-fluoro-4-methylbenzoate

生成物 1

HCID 136574482,5-Dichloro-3-fluoro-4-methylbenzoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The diazonium salt is heated under dry conditions in a glass flask. When the reaction has ended, the crude methyl 2,5-dichloro-3-fluoro-4-methylbenzoate is taken up in 100 ml of 50% strength EtOH, and 8.2 g of KOH are added. The mixture is boiled under reflux for 1 hour and, after cooling to room temperature, is acidified with HCl. The benzoic acid which has precipitated is isolated, dried and recrystallized from toluene. Yield: 11.3 g, melting point 195°-6°.

後処理

  1. additionare added
  2. temperatureunder reflux for 1 hour
  3. customThe benzoic acid which has precipitated
  4. customis isolated
  5. customdried
  6. customrecrystallized from toluene

出典と根拠

ORDレコード
ord-9572f93b969747b3a7fe4cbc771974db
出典データセット
uspto-grants-1988_08
特許番号
US04762844

反応ノート

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