Water → Methyl 3-(3-(2-quinolinylmethyloxy)phenoxymethyl)benzoate

HRID 345923ノート

反応式

HRID 345923 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([OH:19])[CH:16]=[CH:17][CH:18]=1.[C:20](=[O:23])([O-])[O-].[K+].[K+].O.CN([CH:30]=[O:31])C>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:16]=[CH:17][CH:18]=1)[O:19][CH2:4][C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][CH:10]=1)[C:20]([O:31][CH3:30])=[O:23]

参加物

5

反応物 4

HCID 962WaterHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 10988736Phenol, 3-(2-quinolinylmethoxy)-

生成物 1

HCID 10111528Methyl 3-(3-(2-quinolinylmethyloxy)phenoxymethyl)benzoate

反応条件

温度
50 °C

実験手順

A mixture of 3-(2-quinolinylmethyloxy)phenol (2.51 g, 0.01 mol), 1.85 g (0.01 mol) of methyl 3-chloromethyl benzoate, and 1.5 g of potassium carbonate in 30 ml of DMF is heated at 50° C. overnight. The reaction mixture is poured into water, extracted with ethyl acetate and the organic solution separated, dried and evaporated to dryness. Recrystallization from ethyl acetate gives methyl 3-(3-(2-quinolinylmethyloxy)phenoxymethyl)benzoate. (M.P. 93°-94° C.)

後処理

  1. extractionextracted with ethyl acetate
  2. customthe organic solution separated
  3. customdried
  4. customevaporated to dryness
  5. customRecrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-949a670baf644f6a9f94a55f23055752
出典データセット
uspto-grants-1991_10
特許番号
US05059610

反応ノート

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