Potassium Carbonate → alpha-(3-(4-(2-Quinolinylmethyloxy)phenoxymethyl)phenoxy)acetonitrile

HRID 345929ノート

反応式

HRID 345929 の反応式
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[O:6][CH2:7][C:8]#[N:9].[N:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[CH2:23][O:24][C:25]1[CH:31]=[CH:30][C:28]([O-:29])=[CH:27][CH:26]=1.[Na+].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O.O>[N:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[CH2:23][O:24][C:25]1[CH:31]=[CH:30][C:28]([O:29][CH2:2][C:3]2[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=2)[O:6][CH2:7][C:8]#[N:9])=[CH:27][CH:26]=1

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 14774148alpha-(3-Chloromethylphenoxy)acetonitrileHCID 23684421Sodium 4-(2-quinolinylmethyloxy)phenoxide

生成物 1

HCID 14774149alpha-(3-(4-(2-Quinolinylmethyloxy)phenoxymethyl)phenoxy)acetonitrile

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

A mixture of α-(3-chloromethylphenoxy)acetonitrile (0.025 mol), sodium 4-(2-quinolinylmethyloxy)phenoxide (0.025 mol and anhydrous potassium carbonate (0.125 mol) in dimethylsulfoxide (50 ml) is stirred at ambient temperature for 18 hrs. The reaction is diluted with water (600 ml) and extracted with ethyl acetate (3×150 ml). The ethyl acetate solution is washed with water (3×100 ml) and brine (100 ml) then dried and evaporated to give α-(3-(4-(2-quinolinylmethyloxy)phenoxymethyl)phenoxy)acetonitrile. (M.P. 110°-114° C.)

後処理

  1. extractionextracted with ethyl acetate (3×150 ml)
  2. washThe ethyl acetate solution is washed with water (3×100 ml) and brine (100 ml)
  3. customthen dried
  4. customevaporated

出典と根拠

ORDレコード
ord-9f102b87af704166937c4ae48afcdd4c
出典データセット
uspto-grants-1991_10
特許番号
US05059610

反応ノート

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