1-(Thiophen-3-yl)ethanone → 3-Dimethylamino-1-thien-3-ylpropen-1-one

HRID 345967

反応式

HRID 345967 の反応式
[C:1]([C:4]1[CH:8]=[CH:7][S:6][CH:5]=1)(=[O:3])[CH3:2].CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[CH3:11][N:12]([CH3:14])[CH:13]=[CH:2][C:1]([C:4]1[CH:8]=[CH:7][S:6][CH:5]=1)=[O:3]

参加物

3

反応物 2

HCID 151161-(Thiophen-3-yl)ethanoneHCID 78373Dimethylformamide dimethyl acetal

生成物 1

HCID 5964663-Dimethylamino-1-thien-3-ylpropen-1-one収率 87%

実験手順

A mixture of 48.4 g of 3-acetylthiophene and 75 ml of dimethylformamide dimethyl acetal, under nitrogen, is heated for 15 hours on a steam bath. The reaction is concentrated in vacuo and the residue crystallized from methylene chloride/hexane to give 60.55 g (87%) of the desired product, mp 89°-90° C.

後処理

  1. temperatureunder nitrogen, is heated for 15 hours on a steam bath
  2. concentrationThe reaction is concentrated in vacuo
  3. customthe residue crystallized from methylene chloride/hexane

出典と根拠

ORDレコード
ord-f398647fc38b4d5583314e6c8c349f46
出典データセット
uspto-grants-1991_10
特許番号
US05059709

関連ノート

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