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Ethylene → 1-(2-Bromoethyl)-3,5-dimethyl Adamantane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylene | HCID 6325 | — |
| 反応物 | 1-Bromo-3,5-dimethyladamantane | HCID 98317 | — |
| 反応物 | Bromhydrol | HCID 166749 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 1-(2-Bromoethyl)-3,5-dimethyl Adamantane | HCID 15068767 | 48% |
反応手順
Mix 1.4 mol of 1-bromo-3,5-dimethyl adamantane (I) in hexane with 0.6 mol of aluminum bromide at -75° C. Subsequently, pass ethylene through the solution for 20-30 minutes, stir for 5 min., and pour the reaction mixture onto ice water. Extract with ether, dry the organic phase and evaporate to dryness. Recrystallize the residue from methanol. (Yield: 48%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05061703 |
| 出典データセット | uspto-grants-1991_10 |
| ORD ID | ord-8ea37ed7204243fe814166548c4d8d15 |
| 出典メモ | uspto-grants-1991_10 |