反応式
C([C:3]1[CH:8]=[CH:7][C:6]([C:9]([O:11][CH3:12])=[O:10])=[CH:5][N:4]=1)=O.OS(O)(=O)=O.[CH:18]([O:23][CH3:24])([O:21][CH3:22])OC>CO>[CH3:24][O:23][CH:18]([O:21][CH3:22])[C:3]1[CH:8]=[CH:7][C:6]([C:9]([O:11][CH3:12])=[O:10])=[CH:5][N:4]=1参加物
5
実験手順
To a solution of methyl 2-formylpyridine-5-carboxylate (2.00 g, 12.1 mmol) in methanol (20 ml) and trimethyl orthoformate (5 ml) was added H2SO4 (conc., 1.5 ml). After refluxing overnight, the reaction was cooled and concentrated to a thick slurry and then poured into saturated NaHCO3 (50 ml). The latter was extracted with ether (3×30 ml) and the combined organic layers dried (MgSO4) and concentrated to afford title product (1.91 g, 75%).
後処理
- temperatureAfter refluxing overnight
- temperaturethe reaction was cooled
- concentrationconcentrated to a thick slurry
- additionpoured into saturated NaHCO3 (50 ml)
- extractionThe latter was extracted with ether (3×30 ml)
- dry with materialthe combined organic layers dried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-5c2b0597d11440a1a0dae16aa413565e
- 出典データセット
- uspto-grants-1991_10
- 特許番号
- US05061717
関連ノート
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