Ethanol → 4-Bromo-3-fluorobenzaldehyde
反応式
C([O:4][CH:5](OC(=O)C)[C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[C:8]([F:13])[CH:7]=1)(=O)C.C(O)C.O.S(=O)(=O)(O)O>CCOCC>[Br:12][C:9]1[CH:10]=[CH:11][C:6]([CH:5]=[O:4])=[CH:7][C:8]=1[F:13]参加物
6
実験手順
A mixture of 4-bromo-3-fluorobenzylidene diacetate (15 g), ethanol (41 ml), water (41 ml) and concentrated sulphuric acid (4 ml) was heated to reflux for 3 hours. After cooling, ether (300 ml) was added and the aqueous layer separated. The organic phase was washed with saturated sodium carbonate and brine before drying over anhydrous magnesium sulphate and evaporation in vacuo. 4-Bromo-3-fluorobenzaldehyde was obtained as a solid (7.3 g).
後処理
- temperaturewas heated
- temperatureto reflux for 3 hours
- temperatureAfter cooling
- customthe aqueous layer separated
- washThe organic phase was washed with saturated sodium carbonate and brine
- dry with materialbefore drying over anhydrous magnesium sulphate and evaporation in vacuo
出典と根拠
- ORDレコード
- ord-b2bf3b052c1e4a8cba5a34f25d501af9
- 出典データセット
- uspto-grants-1991_10
- 特許番号
- US05061726
反応ノート
読み込み中…