化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → Methyl 4-carbamothioylbenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Methyl 4-cyanobenzoate | HCID 70791 | — |
| 反応物 | HCID 178418634 | HCID 178418634 | — |
| 溶媒 | Propan-2-ol--water (1/1) | HCID 21889133 | — |
| 生成物 | Methyl 4-carbamothioylbenzoate | HCID 11401319 | 77.7% |
反応手順
130 g (1.7 moles) of thioacetic acid, 50 g (0.3 mole) of methyl 4-cyanobenzoate and 12 ml of glacial acetic acid were stirred for 2 hours at 80° C. The mixture was allowed to cool, 200 ml of 1:1 isopropanol/water was added, the mixture was stirred for a short time and the crystals formed were filtered off under suction. 45.5 g of 4-carbomethoxybenzothiamide of melting point 188°-190° C. were obtained in this manner.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05061705 |
| 出典データセット | uspto-grants-1991_10 |
| ORD ID | ord-981319bd557c4bf2a449627f74850574 |
| 出典メモ | uspto-grants-1991_10 |