反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].Cl[C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=2)[N:13]=[CH:12][N:11]=1>>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1参加物
3
実験手順
In one particular, 3-bromoaniline is reacted with 4-chloro-6-nitroquinazoline to produce 4-[(3-bromophenyl)amino]-6-nitroquinazoline, which is reduced thereafter, by means of an ethanolic solution of hydrazine hydrate and Raney®Nickel, to the corresponding 6-aminoquinazoline. The 4-[(3-bromophenyl)amino]-6-aminoquinazoline is then reacted with bistributyltin in the presence of tetrakis(triphenylphosphine)palladium in THF solution and the obtained stanylated product is reacted thereafter with iodine 124, as described hereinabove. The obtained iodine-124 labeled 4-[(3-iodophenyl)amino]-6-aminoquinazoline is then reacted with an acryloyl chloride to produce an iodine-124 labeled N-{4-[(3-iodophenyl)amino]quinazoline-6-yl}acrylamide.
出典と根拠
- ORDレコード
- ord-ca79e803613542d183b201e01dcdbc03
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07172749B2
関連ノート
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