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Isopropanol → N4-Phenylquinazoline-4,6-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 6-Nitro-N-phenylquinazolin-4-amine | HCID 5328189 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | N4-Phenylquinazoline-4,6-diamine | HCID 5328187 | — |
反応手順
A solution of 4-(phenylamino)-6-nitroquinazoline in ethanol/water and a polar solvent such as iso-propylalcohol is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel. The reaction mixture is filtered, evaporated and purified by silica gel chromatography, to give the product, 4-(phenylamino)-6-aminoquinazoline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07172749B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-79f0fa1082b04b518e2114cf8bffea1e |
| 出典メモ | uspto-grants-2007_02 |