反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].Cl[C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=2)[N:13]=[CH:12][N:11]=1>C(O)(C)C>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1参加物
4
実験手順
3-Bromoaniline (1.72 grams, 10 mmol) was reacted with 4-chloro-6-nitroquinazoline (523 mg, 2.5 mmol), in iso-propylalcohol, as is described hereinabove, to give 4-[(3-bromophenyl)amino]-6-nitroquinazoline (823 mg, 95% yield), which was thereafter reacted (590 mg, 1.7 mmol) with hydrazine hydrate, according to the procedure described hereinabove, to give 4-[(3-bromophenyl)amino]-6-aminoquinazoline (332 mg, 62% yield).
出典と根拠
- ORDレコード
- ord-6b124bb44fff450f8df54ca562c21af8
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07172749B2
関連ノート
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