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Benzaldehyde → 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methylbenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Pyrrole-2-carboxaldehyde | HCID 13854 | — |
| 反応物 | 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid | HCID 13500657 | — |
| 生成物 | 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methylbenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid | HCID 14230012 | — |
反応手順
In the described fashion of Example 1 replacing benzaldehyde with with 2-pyrrolecarboxaldehyde and using the acid (1) (R=cyclopropyl) described in Example 19 one can obtain 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(2-pyrrylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid (3) (R=cyclopropyl, Z=2-pyrrole).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762845 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-c8c9b6e13349460dbfe48136a8f7c85d |
| 出典メモ | uspto-grants-1988_08 |