化工社化工社 化学情報印刷レポート · 研究参考用
2-Ethylpropanedioyl dichloride → 3-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-3-oxo-propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Ethylpropanedioyl dichloride | HCID 10920924 | — |
| 反応物 | 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride | HCID 21080184 | — |
| 反応物 | 3-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-3-oxo-propionic acid ethyl ester | HCID 69290734 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 3-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-3-oxo-propionamide | HCID 11772683 | 70% |
反応手順
3-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-3-oxo-propionic acid ethyl ester: The title compound was prepared in analogy to Example 1d) from 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride [Example 1c)] and ethyl malonic acid chloride with triethylamine as the base. Yield: 70% of theory as a colourless oil; MS: m/e=386 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07173023B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-0cc9c9d9b5fb4a71ae071e7b3c235fb3 |
| 出典メモ | uspto-grants-2007_02 |