化工社化工社 化学情報印刷レポート · 研究参考用
Methyl chloroformate → 7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic Acid Methyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl chloroformate | HCID 6586 | — |
| 反応物 | 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride | HCID 21080184 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic Acid Methyl Ester | HCID 11186517 | 95% |
反応手順
The title compound was prepared in analogy to Example 1d) from 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride [Example 1c)] and methyl chloroformate with triethylamine as the base. Yield: 95% of theory as a colourless oil; MS: m/e=330 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07173023B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-17a7465a1e4348db8c123b7186989223 |
| 出典メモ | uspto-grants-2007_02 |