反応式
Cl.[F:2][C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[CH2:6][O:7][C:8]1[CH:18]=[CH:17][C:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:10]=2[CH:9]=1.Br[CH:23]([CH3:27])[C:24]([NH2:26])=[O:25].C(=O)([O-])[O-].[K+].[K+]>>[F:2][C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[CH2:6][O:7][C:8]1[CH:18]=[CH:17][C:11]2[CH2:12][CH2:13][N:14]([CH:23]([CH3:27])[C:24]([NH2:26])=[O:25])[CH2:15][CH2:16][C:10]=2[CH:9]=1参加物
4
実験手順
The title compound was prepared in analogy to Example 10 from 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride [Example 1c)] and (RS)-2-bromo-propionamide with potassium carbonate as the base. Yield: 85% of theory as a white solid; MS: m/e=343 (M+H)+.
出典と根拠
- ORDレコード
- ord-7ce536f878274c26aac0a28349c12df8
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07173023B2
関連ノート
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