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Benzaldehyde → 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methoxybenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | 4-Aminobenzaldehyde | HCID 11158 | — |
| 反応物 | 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid | HCID 13500657 | — |
| 生成物 | 1-p-Fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methoxybenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid | HCID 14230019 | — |
反応手順
In the described fashion of Example 1 replacing benzaldehyde with 4-aminobenzaldehyde and using the acid (1) (R=cyclopropyl) described in Example 19 one obtains 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-aminobenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid (3) (R=cyclopropyl, Z=p-aminophenyl).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762845 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-3cc87435745e468a9cc0d5196ec0bb41 |
| 出典メモ | uspto-grants-1988_08 |