化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Carbonate → (R)-3-chloro-N-(3-{2-[(3-fluorophenyl)thio]propyl}-1,2,4-thiadiazol-5-yl)-2-methylbenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | m-Fluorobenzenethiol | HCID 75710 | — |
| 反応物 | HCID 86595861 | HCID 86595861 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (R)-3-chloro-N-(3-{2-[(3-fluorophenyl)thio]propyl}-1,2,4-thiadiazol-5-yl)-2-methylbenzenesulfonamide | HCID 16119014 | — |
反応手順
(R)-2-(5-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,2,4-thiadiazol-3-yl)-1-methylethyl 3-chloro-2-methylbenzenesulfonate (example 98), 3-fluorothiophenol (1 eq) and sodium carbonate (1 eq) in CH3CN were heated overnight. Standard work-up and purification yielded the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07173030B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-b45a8fbabee84cd3a770253cd1beedb7 |
| 出典メモ | uspto-grants-2007_02 |