関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Bromopropionic acid | HCID 11729 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | HCID 178470113 | HCID 178470113 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Carboxy-2-carboxyethylthio-1,3-thiazole | HCID 14415208 | — |
反応手順
6.9 g of bromopropionic acid were dissolved in 100 ml of water, and the pH was adjusted to 7 with 1N NaOH. This solution was added dropwise to a suspension of 7.5 g of 4-ethoxycarbonyl-2-mercapto-1,3-thiazole in 75 ml of H2O. The pH was adjusted to 8-10 with 2N NaOH, and the mixture was stirred at room temperature for 4 h and at 60° C. for 2 h. The pH was maintained between 8 and 10. While cooling in ice, the mixture was acidified to pH 1 with 2N HCl, and the product was filtered off.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04762848 |
|---|
| 出典データセット | uspto-grants-1988_08 |
|---|
| ORD ID | ord-437e342210694b3fa36739d83cf07047 |
|---|
| 出典メモ | uspto-grants-1988_08 |
|---|
