Potassium Carbonate → 4-[(1H-1,3-benzodiazol-2-ylsulfanyl)methyl]benzoic acid

HRID 34671

反応式

HRID 34671 の反応式
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([OH:27])=[O:26])=[CH:21][CH:20]=1>CN(C=O)C>[C:25]([C:22]1[CH:23]=[CH:24][C:19]([CH2:18][S:1][C:2]2[NH:3][C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[N:6]=2)=[CH:20][CH:21]=1)([OH:27])=[O:26]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 225994-(Bromomethyl)benzoic acidHCID 178527775HCID 178527775、化合物

生成物 1

HCID 49921594-[(1H-1,3-benzodiazol-2-ylsulfanyl)methyl]benzoic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

4.6 g (30 mmol) of 2-mercaptobenzimidazole were initially introduced into 60 ml of dry DMF, 8.3 g (60 mmol) of K2CO3 were added, and a solution of 6.7 g (31 mmol) of α-bromo-4-toluic acid in 15 ml of dry DMF was added dropwise at room temperature. After 4 hours, a solid residue was filtered off with suction, the DMF was removed in vacuo, and the residue was taken up in aqueous hydrochloric acid at pH 2. Crystals of the title compound separated out, and these were washed with water, methanol and ether and dried.

後処理

  1. additionwere added
  2. filtrationa solid residue was filtered off with suction
  3. customthe DMF was removed in vacuo
  4. customCrystals of the title compound separated out
  5. washthese were washed with water, methanol and ether
  6. customdried

出典と根拠

ORDレコード
ord-934a558e455a4a6d9a5a76c76274324d
出典データセット
uspto-grants-1988_08
特許番号
US04762848

関連ノート

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