Methyl chloroacetate → N-(3,5-difluorobenzyl)-glycine methyl ester

HRID 34675

反応式

HRID 34675 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:10])[CH:9]=1)[CH2:5][NH2:6].Cl[CH2:12][C:13]([O:15][CH3:16])=[O:14].C(N(CC)CC)C>CN(C)C=O.CCOCC>[CH3:16][O:15][C:13](=[O:14])[CH2:12][NH:6][CH2:5][C:4]1[CH:3]=[C:2]([F:1])[CH:9]=[C:8]([F:10])[CH:7]=1

参加物

6

反応物 3

HCID 7295Methyl chloroacetateHCID 8471TriethylamineHCID 1452113,5-Difluorobenzylamine

生成物 1

HCID 14479943N-(3,5-difluorobenzyl)-glycine methyl ester収率 41%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

A solution of 3,5-difluorobenzylamine prepared as above (12.3 g, 0.0863 mole), methyl chloroacetate (7.6 ml, 0.0863 mole) and triethylamine (12.0 ml, 0.0863 mole) in dry dimethylformamide (85 ml) was heated at 60° C. for 3 hours. The mixture was diluted with an equal volume of ether and the triethylamine hydrochloride filtered. The filtrate was concentrated under vacuum, the resultant oil triturated with ethyl acetate, and the solution decanted from a small amount of residual oil. The solvent was removed and the product was purified by flash chromatography (silica) by eluting with hexane-ethyl acetate (70:30) to give N-(3,5-difluorobenzyl)glycine methyl ester as an oil (7.61 g, 41%).

後処理

  1. filtrationthe triethylamine hydrochloride filtered
  2. concentrationThe filtrate was concentrated under vacuum
  3. customthe resultant oil triturated with ethyl acetate
  4. customthe solution decanted from a small amount of residual oil
  5. customThe solvent was removed
  6. customthe product was purified by flash chromatography (silica)
  7. washby eluting with hexane-ethyl acetate (70:30)

出典と根拠

ORDレコード
ord-0f6f6c32b11746209f46436a83cc9ba0
出典データセット
uspto-grants-1988_08
特許番号
US04762850

関連ノート

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