HCID 178453697、化合物 → Formate
反応式
C([O:5][C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]([C:14]1[N:18]([CH2:19][C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([F:27])[CH:21]=2)[C:17]([SH:28])=[N:16][CH:15]=1)=[O:13])=[O:7])(C)(C)C>C(O)=O>[NH2:8][CH2:9][CH2:10][NH:11][C:12]([C:14]1[N:18]([CH2:19][C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([F:27])[CH:21]=2)[C:17]([SH:28])=[N:16][CH:15]=1)=[O:13].[CH:6]([O-:7])=[O:5]参加物
4
実験手順
A solution of N-(t-butyloxycarbonylaminoethyl)-1-(3,5-diflurobenzyl)-2-mercaptoimidazole-5-carboxamide (1.29 g, 3.13 mmole) prepared as above in 98% formic acid (40 ml) was stirred under an argon atmosphere for 3 hours and the solvent was removed under vacuum. The resulting oil was triturated with ether, and the product was filtered and dried to give N-(2-aminoethyl)-1(3,5-difluorobenzyl)-2-mercaptoimidazole-5-carboxamide, formate, m.p.: 195°-196° C. (0.630 g, 56%).
後処理
- custom