化工社化工社 化学情報印刷レポート · 研究参考用
Benzyl Bromide → 1-benzyl-2-methyl-2,3-dihydro-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Methylindoline | HCID 23305 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-benzyl-2-methyl-2,3-dihydro-1H-indole | HCID 10513589 | 101.5% |
反応手順
To a solution of 1 g (7.5 mmol) of 2-methyl-2,3-dihydro-1H-indole in anhydrous DMF were added 1.03 g (7.5 mmol) of K2CO3 and then dropwise 0.97 mL (8.0 mmol) of benzylbromide. The mixture was stirred at RT for 3hrs and then distributed between Et2O and a saturated aqueous solution of NH4Cl. The combined organic phases were dried over Na2SO4 and evaporated to yield 1.7 g (quantitative) of crude 1-benzyl-2-methyl-2,3-dihydro-1H-indole, light blue oil, MS: 224 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07173048B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-2a2f6613161d4ab09e81152c621626b0 |
| 出典メモ | uspto-grants-2007_02 |