1-(4-(Trifluoromethyl)phenyl)ethan-1-one → 5-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

HRID 346853ノート

反応式

HRID 346853 の反応式
[Cl:1][CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[C:13](OC)[C:12](OC)=[C:11](OC)[CH:10]=2)[CH:4]=1.CC(C1C=CC([C:30]([F:33])([F:32])[F:31])=CC=1)=O>>[Cl:1][CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:30]([F:33])([F:32])[F:31])=[CH:11][CH:10]=2)[CH:4]=1

参加物

3

反応物 2

HCID 697311-(4-(Trifluoromethyl)phenyl)ethan-1-oneHCID 184084865-Chloromethyl-1-methyl-3-(3,4,5-trimethoxy-phenyl)pyrazole

生成物 1

HCID 210822245-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

実験手順

5-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole was prepared in analogy to the preparation of 5-chloromethyl-1-methyl-3-(3,4,5-trimethoxy-phenyl)-1H-pyrazole described by Kodama et al. (U.S. Pat. No. 6,472,386), but starting from 4-trifluoromethylacetophenone instead of 3′4′5′-trimethoxyacetophenone.

出典と根拠

ORDレコード
ord-d47885a2419d4141bea517bc27107419
出典データセット
uspto-grants-2007_02
特許番号
US07173048B2

反応ノート

読み込み中…