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1-Methylcyclopropane-1-sulfonamide → HCID 68748369、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methylcyclopropane-1-sulfonamide | HCID 21889814 | — |
| 反応物 | 14-Tert-butoxycarbonylamino-18-(isoquinolin-1-yloxy)-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.04,6]-nonadec-7-ene-4-carboxylic acid | HCID 72427434 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | HCID 68748369 | HCID 68748369 | 58.1% |
反応手順
Prepared from 14-tert-butoxycarbonylamino-18-(isoquinolin-1-yloxy)-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.04,6]-nonadec-7-ene-4-carboxylic acid etherate (105 mg, 0.177 mmol) and 1-methyl-cyclopropanesulfonic acid amide (31 mg, 0.23 mmol, prepared as described above). Flash chromatography (2% methanol/methylene chloride) gave 73 mg (58%) of [18-(isoquinolin-1-yloxy)-4-(1-methyl-cyclopropanesulfonylaminocarbonyl)-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.04,6]nonadec-7-en-14-yl]-carbamic acid tert-butyl ester as a white powder: LC-MS (Method A, retention time: 3.50 min), MS m/z 710 (M++1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07173004B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-db9b0744513e4e4799610ef81c5aa6b8 |
| 出典メモ | uspto-grants-2007_02 |