Tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)but-2-enoate → Tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)butyrate

HRID 347417ノート

反応式

HRID 347417 の反応式
[CH2:1]([C:3](=[CH:11][CH2:12][C@H:13]1[CH2:18][CH2:17][CH2:16][C@@H:15]([OH:19])[CH2:14]1)[C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5])[CH3:2]>CO>[CH2:1]([CH:3]([CH2:11][CH2:12][C@H:13]1[CH2:18][CH2:17][CH2:16][C@@H:15]([OH:19])[CH2:14]1)[C:4]([O:6][C:7]([CH3:10])([CH3:8])[CH3:9])=[O:5])[CH3:2]

参加物

3

反応物 1

HCID 69494094Tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)but-2-enoate

生成物 1

HCID 69494197Tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)butyrate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1.65 g of tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)but-2-enoate are dissolved in 50 ml of methanol, and 100 mg of Perlmans catalyst are added. The mixture is stirred under an atmosphere of hydrogen for 24 hours. The catalyst is filtered off through Celite, and the filtrate is then concentrated under reduced pressure. This gives 1.49 g of tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)butyrate as a colorless oil. C16H30O3 (270.40), Rf(n-heptane:ethyl acetate=5:1)=0.10.

後処理

  1. addition100 mg of Perlmans catalyst are added
  2. filtrationThe catalyst is filtered off through Celite
  3. concentrationthe filtrate is then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-7d160a2e317b4bd79e0bfc927ce8188c
出典データセット
uspto-grants-2007_02
特許番号
US07173151B2

反応ノート

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