2,3-Dihydroxybenzoic Acid → Methyl 2,3-Dihydroxybenzoate

HRID 347423

反応式

HRID 347423 の反応式
[OH:1][C:2]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:12]O>S(=O)(=O)(O)O>[OH:1][C:2]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:12])=[O:5]

参加物

4

反応物 2

HCID 192,3-Dihydroxybenzoic AcidHCID 887Methanol

生成物 1

HCID 75484Methyl 2,3-Dihydroxybenzoate

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

反応条件

温度
60 °C

実験手順

A mixture of 2,3-dihydroxybenzoic acid (5 g), methanol (50 ml) and concentrated sulphuric acid (10 drops) was stirred and heated to 60° C. for 24 hours. The mixture was evaporated and the residue was taken up in ethyl acetate. The organic solution was washed with a saturated solution of sodium bicarbonate, dried over magnesium sulphate and evaporated to give methyl 2,3-dihydroxybenzoate (2.19 g); NMR Spectrum: (CDCl3) 3.95 (s, 3H), 5.7 (s, 1H), 6.8 (t, 1H), 7.15 (d, H), 7.35 (d, H).

後処理

  1. customThe mixture was evaporated
  2. washThe organic solution was washed with a saturated solution of sodium bicarbonate
  3. dry with materialdried over magnesium sulphate
  4. customevaporated

出典と根拠

ORDレコード
ord-01b3ba40aa394ef9b037ac4e40daa3bc
出典データセット
uspto-grants-2007_02
特許番号
US07173135B2

関連ノート

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