化工社化工社 化学情報印刷レポート · 研究参考用
Isovaleryl chloride → 1-{N-[3-(3-methylbutanamido)propyl]-tetradecanamido}-5-(4,6-dimethyl-2-pyrimidylamino)pentane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isovaleryl chloride | HCID 66054 | — |
| 反応物 | 1-[N-(3-aminopropyl)tetradecanamido]-5-(4,6-dimethyl-2-pyrimidylamino)pentane | HCID 14346020 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 1-{N-[3-(3-methylbutanamido)propyl]-tetradecanamido}-5-(4,6-dimethyl-2-pyrimidylamino)pentane | HCID 14346021 | — |
反応手順
The primary amine XV was treated with 3-methylbutanoyl chloride in pyridine in the manner described above (C). The crude product was chromatographed on a 24 g silica gel column (BioSil A) of dimensions 1 cm (id)×30 cm, developed with 30% acetone/CHCl3. Five ml fractions were collected. The pure product was found in tubes 14-22, 128 mg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762949 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-fe2d28c06bf84c46b92c4d5abeabde8a |
| 出典メモ | uspto-grants-1988_08 |