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N-(4-Bromobutyl)phthalimide → 4-Amino-2-(4-phthalimidobutylthio)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(4-Bromobutyl)phthalimide | HCID 93575 | — |
| 反応物 | 1,5-Diazabicyclo(5,4,0)undec-5-ene | HCID 314112 | — |
| 反応物 | HCID 178507915 | HCID 178507915 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Amino-2-(4-phthalimidobutylthio)pyrimidine | HCID 21298754 | 86.7% |
反応手順
A mixture of 2-thiocytosine (0.25 g.), 1,5-diazabicyclo[5,4,0]undec-5-ene (0.33 g.), ethanol (10 ml.) and N-(4-bromobutyl)phthalimide (0.62 g.) was stirred at room temperature for 18 hours and then evaporated to dryness. The residue was partitioned between water and ethyl acetate and the ethyl acetate phase was dried and evaporated to dryness. The residue was recrystallised from acetonitrile to give 4-amino-2-(4-phthalimidobutylthio)pyrimidine (0.56 g.), m.p. 164°-167°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762932 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-a682a20e344347838a09dbb729f50832 |
| 出典メモ | uspto-grants-1988_08 |