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Methanol → Methyl (2-chlorophenyl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | o-Chlorophenylacetic acid | HCID 17124 | — |
| 触媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | Methyl (2-chlorophenyl)acetate | HCID 93683 | 97.5% |
反応手順
To 2-chlorophenylacetic acid (1.04 g, 6 mmol) in MeOH (25 mL) was added sulfuric acid (6 drops) and the solution was refluxed for 16 hours. After concentration, the residue was taken up in ethyl acetate and washed with sat'd aq. NaHCO3, H2O and brine. The organic layer was dried over Na2SO4 and concentrated to give methyl (2-chlorophenyl)acetate 6a (1.08 g, 97.5% ) as a yellowish oil. GCMS (EI) m/z 184, 186 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07176211B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-3743fead2e244e8f877581d62ad96443 |
| 出典メモ | uspto-grants-2007_02 |