3-Hydroxybenzaldehyde → 2-Chloro-3-hydroxybenzaldehyde

HRID 347783

反応式

HRID 347783 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].C(O[Cl:15])(C)(C)C>CC(O)=O>[Cl:15][C:3]1[C:2]([OH:1])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[O:6]

参加物

4

反応物 2

HCID 1013-HydroxybenzaldehydeHCID 521297Tert-Butyl hypochlorite

生成物 1

HCID 5933762-Chloro-3-hydroxybenzaldehyde収率 55%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a suspension of 3-hydroxybenzaldehyde (20.12 g, 160 mmol) in HOAc (40 mL) was added carefully tBuOCl (20 mL, 176 mmol) with stirring. The reaction became a clear solution and strongly exothermic. It was allowed to cool and stirred for 16 hours, resulting in a white precipitate. The solid was filtered, washed with H2O and dried to give 2-chloro-3-hydroxybenzaldehyde (13.77 g, 55% ), GCMS (El) m/z 156, 158 (M+).

後処理

  1. temperatureto cool
  2. stirringstirred for 16 hours
  3. customresulting in a white precipitate
  4. filtrationThe solid was filtered
  5. washwashed with H2O
  6. customdried

出典と根拠

ORDレコード
ord-af753c20d3334f6db41d0a87250830dc
出典データセット
uspto-grants-2007_02
特許番号
US07176211B2

関連ノート

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