化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → Oxane-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 2H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester | HCID 2773520 | — |
| 生成物 | Oxane-4-carboxamide | HCID 13197203 | 74.6% |
反応手順
Concentrated aqueous ammonia (50 mL) was added to methyl tetrahydro-2H-pyran-4-carboxylate (50 g, 347 mmol) and the reaction mixture was stirred for 43.5 hours at room temperature. The reaction mixture was then cooled in an ice water bath, after which the precipitate was filtered out and dried under reduced pressure at 40° C. to afford 33.4 g of the title compound (74.6% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07176216B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-252e002dbf1d499fbd2f04606d198237 |
| 出典メモ | uspto-grants-2007_02 |