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2-(Methylthio)pyrimidin-4-amine → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-methylthiopyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Methylthio)pyrimidin-4-amine | HCID 259225 | — |
| 反応物 | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-methylthiopyrimidine | HCID 54247278 | 51.2% |
反応手順
A mixture of 4-amino-2-methylthiopyrimidine (2.1 g.), 2,2,2-trifluoroethylisothiocyanate (2.8 g.) and acetonitrile (5 ml.) was stirred at 70° for 72 hours and then cooled, and the solid that crystallised was collected to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-methylthiopyrimidine (2.15 g.) which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762932 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-7d02c212b0174ca7822449c59ef637eb |
| 出典メモ | uspto-grants-1988_08 |