3-[2-(2,2,2-Trifluoroethyl)guanidino]-1-(2-cyanoethyl)pyrazole → 3-[2-(2,2,2-Trifluoroethyl)guanidino]-1-(3-aminopropyl)pyrazole

HRID 34803ノート

反応式

HRID 34803 の反応式
[F:1][C:2]([F:18])([F:17])[CH2:3][N:4]=[C:5]([NH2:16])[NH:6][C:7]1[CH:11]=[CH:10][N:9]([CH2:12][CH2:13][C:14]#[N:15])[N:8]=1>[Ni].N>[F:18][C:2]([F:1])([F:17])[CH2:3][N:4]=[C:5]([NH2:16])[NH:6][C:7]1[CH:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][NH2:15])[N:8]=1

参加物

4

反応物 1

HCID 212988793-[2-(2,2,2-Trifluoroethyl)guanidino]-1-(2-cyanoethyl)pyrazole

生成物 1

HCID 212987663-[2-(2,2,2-Trifluoroethyl)guanidino]-1-(3-aminopropyl)pyrazole

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 222Ammonia溶媒

実験手順

A mixture of 3-[2-(2,2,2-trifluoroethyl)guanidino]-1-(2-cyanoethyl)pyrazole (0.32 g.), saturated ethanolic ammonia (10 ml.) and Raney nickel (0.2 g.) was stirred vigorously under an atmosphere of hydrogen at room temperature and atmospheric pressure for 3 hours. The mixture was filtered and the filtrate evaporated to dryness to give 3 -[2-(2,2,2-trifluoroethyl)guanidino]-1-(3-aminopropyl)pyrazole which was used without further purification.

後処理

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated to dryness

出典と根拠

ORDレコード
ord-10b6d9022f6549f198ce9ae1eccaf0c0
出典データセット
uspto-grants-1988_08
特許番号
US04762932

反応ノート

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