化工社化工社 化学情報印刷レポート · 研究参考用
HRID 348044作成日：2026年10月26日
Dabco → 1-[4-(4-{1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl}phenoxymethyl)benzyl]-4-aza-1-azoniabicyclo[2.2.2]octane bromide
https://huagongshe.com/reaction/348044
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dabco | HCID 9237 | — |
| 反応物 | 4-[4-(4-Bromomethylbenzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one | HCID 21083190 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-[4-(4-{1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl}phenoxymethyl)benzyl]-4-aza-1-azoniabicyclo[2.2.2]octane bromide | HCID 21083157 | — |
反応手順
180 mg of (12) and 300 mg of 1,4-diazabicyclo[2.2.2]octane (DABCO) were dissolved in 5 ml of toluene and stirred at 80° C. for 90 min. After the reaction ended, the mixture was allowed to cool and the colorless solid was filtered off with suction. This gave 195 mg of product (13) of molecular weight 704.66 (C38H40BrF2N3O3); MS (ESI): 624.30 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07176194B2 |
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| 出典データセット | uspto-grants-2007_02 |
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| ORD ID | ord-415c9c1ff1584f0989e8ec94edd54a7c |
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| 出典メモ | uspto-grants-2007_02 |
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