3,4-Dimethylphenol → HCID 17024601、化合物
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].C([O-])([O-])=O.[Cs+].[Cs+].Br[CH:17]([CH3:23])[C:18]([O:20][CH2:21][CH3:22])=[O:19]>CN(C=O)C>[CH2:21]([O:20][C:18](=[O:19])[CH:17]([O:9][C:4]1[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=1)[CH3:23])[CH3:22]参加物
5
反応条件
- 温度
- 90 °C
実験手順
3,4-Dimethylphenol (0.30 mol), Cs2CO3 (197.0 g, 0.61 mol), and ethyl 2-bromopropionate (54.3 g, 0.30 mol) were combined in anhydrous DMF (1000 mL) and stirred at 90° C. under an atmosphere of nitrogen. After 16 h, the DMF was removed in vacuo. The residue was dissolved in ethyl acetate (300 mL) and washed twice with water and once with brine. The organic layer was dried over Na2SO4 and concentrated in vacuo to produce an oil.
後処理
- customthe DMF was removed in vacuo
- dissolutionThe residue was dissolved in ethyl acetate (300 mL)
- washwashed twice with water and once with brine
- dry with materialThe organic layer was dried over Na2SO4
- concentrationconcentrated in vacuo
- customto produce an oil
出典と根拠
- ORDレコード
- ord-6364cbedda7e4f24930ce4a363501fea
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07176224B2
反応ノート
読み込み中…