Triethylamine → (2R)-Butan-2-YL methanesulfonate

A solution of methanesulphonic anhydride (8.33 g, 47.8 mmol) in dichloromethane (30 ml) was added dropwise over 30 minutes to an ice-cooled solution of (R)-2-butanol (4.0 ml, 43.5 mmol) and triethylamine (6.65 ml, 47.8 mmol) in dichloromethane (70 ml). The reaction was then allowed to warm to room temperature and stirred for 18 hours. The mixture was then washed with water, 2N hydrochloric acid, then dried (Na2SO4) and evaporated under reduced pressure to give the title compound as a pale yellow oil, 7.0 g.

1. washThe mixture was then washed with water, 2N hydrochloric acid
2. dry with materialdried (Na2SO4)
3. customevaporated under reduced pressure

ORDレコード

ord-90301e4243ad4986aac61da05fd1e19a

出典データセット

uspto-grants-2007_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07176311B2