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2-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridin-3-ol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-yl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridin-3-ol | HCID 2774691 | — |
| 反応物 | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| 生成物 | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-yl ester | HCID 69523459 | 28% |
反応手順
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-ol (32 mg, 0.17 mmol) as the source alcohol. Chromatographic (30–40% ethyl acetate/hexane) purification yielded 22 mg (28%) of the titled compound. ESI-MS t/z 462 (MH+), 460 (M−H−).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07176310B1 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-6bf752b0309a4bf8a2d5128e0253f2b9 |
| 出典メモ | uspto-grants-2007_02 |