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3,3-Dimethyl-1-butanol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 3,3-dimethyl-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,3-Dimethyl-1-butanol | HCID 12233 | — |
| 反応物 | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| 生成物 | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 3,3-dimethyl-butyl ester | HCID 69523345 | 85% |
反応手順
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 3,3-dimethylbutanol (26 mg, 0.26 mmol) as the coupling partner. Concentration (no chromatography) yielded 54 mg (85%) of the titled compound. ESI-MS m/z 376 (MH+), 374 (M−H−).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07176310B1 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-e17d57388c55403aa2bed5fa9b19099d |
| 出典メモ | uspto-grants-2007_02 |