化工社化工社 化学情報印刷レポート · 研究参考用
2-(Tricyclo(3.3.1.1'3,7)dec-1-yl)ethanol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-adamantan-1-yl-ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Tricyclo(3.3.1.1'3,7)dec-1-yl)ethanol | HCID 110810 | — |
| 反応物 | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| 生成物 | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-adamantan-1-yl-ethyl ester | HCID 69522587 | 75% |
反応手順
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 1-adamantaneethanol (27 mg, 0.15 mmol) as the coupling partner. Concentration (no chromatography) yielded 58 mg (75%) of the titled compound. ESI-MS m/z 454 (MH+), 452 (M−H−).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07176310B1 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-e6c4e900255f4da29ea14e6aeb60ee08 |
| 出典メモ | uspto-grants-2007_02 |