2-(Tricyclo(3.3.1.1'3,7)dec-1-yl)ethanol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-adamantan-1-yl-ethyl ester

HRID 348472

反応式

HRID 348472 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][C:14]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[N:15][CH:16]=2)=[O:10])=[CH:4][CH:3]=1.[C:22]12([CH2:32][CH2:33]O)[CH2:31][CH:26]3[CH2:27][CH:28]([CH2:30][CH:24]([CH2:25]3)[CH2:23]1)[CH2:29]2>>[C:22]12([CH2:32][CH2:33][O:20][C:19](=[O:21])[CH2:18][O:17][C:14]3[N:13]=[CH:12][C:11]([C:9](=[O:10])[NH:8][C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=4)=[CH:16][N:15]=3)[CH2:23][CH:24]3[CH2:30][CH:28]([CH2:27][CH:26]([CH2:25]3)[CH2:31]1)[CH2:29]2

参加物

3

反応物 2

HCID 1108102-(Tricyclo(3.3.1.1'3,7)dec-1-yl)ethanolHCID 21087356[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid

生成物 1

HCID 69522587[5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-adamantan-1-yl-ethyl ester収率 75%

実験手順

The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 1-adamantaneethanol (27 mg, 0.15 mmol) as the coupling partner. Concentration (no chromatography) yielded 58 mg (75%) of the titled compound. ESI-MS m/z 454 (MH+), 452 (M−H−).

後処理

  1. concentrationConcentration (no chromatography)

出典と根拠

ORDレコード
ord-e6c4e900255f4da29ea14e6aeb60ee08
出典データセット
uspto-grants-2007_02
特許番号
US07176310B1

関連ノート

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