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Acetic Acid → 2-[(4-Chlorophenylthio)methylamino]-4-methoxy-6-methylpyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | p-Chlorothiophenol | HCID 7815 | — |
| 反応物 | 4-Methoxy-6-methylpyrimidin-2-amine | HCID 587236 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-[(4-Chlorophenylthio)methylamino]-4-methoxy-6-methylpyrimidine | HCID 23043234 | — |
反応手順
A mixture of 13.99 g of 2-amino-4-methoxy-6-methylpyrimidine (0.1 mole), 14.8 g of 4-chlorothiophenol (0.1 mole), 9.4 g of aqueous 35% formaldehyde (0.11 mole) and 1 g of acetic acid are heated under reflux for 1 hour in 100 ml of methanol. The resultant solution is clarified by filtration, diluted with 150 ml of toluene and then the solvent is removed in a rotary evaporator. The residue crystallises after standing for some time. The melting point is 78°-82° after recrystallisation from hexane. The yield is 24 g (81% of theory).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764203 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-f56531faf056450bba8134dfded76144 |
| 出典メモ | uspto-grants-1988_08 |