6-(Bromomethyl)-2-methylquinoline → 2-(2-Methylquinolin-6-ylmethyl)-isoindole-1,3-dione

HRID 348724

反応式

HRID 348724 の反応式
Br[CH2:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([CH3:13])[CH:7]=[CH:6]2.[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.[K]>CN(C=O)C>[CH3:13][C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([CH2:2][N:18]3[C:14](=[O:24])[C:15]4[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=4)[C:17]3=[O:19])[CH:4]=2)[N:9]=1

参加物

4

反応物 2

HCID 27954806-(Bromomethyl)-2-methylquinolineHCID 24194345Phthalimide potassium salt

生成物 1

HCID 230791882-(2-Methylquinolin-6-ylmethyl)-isoindole-1,3-dione収率 99.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The compound (421.7 mg) obtained in Example 119-1 was dissolved in anhydrous DMF (12.6 ml) and added with potassium phthalimide (663.1 mg), followed by stirring at room temperature for 2 hours. After the reaction, the solvent was distilled off and the residue was then added with water. The mixture was extracted with chloroform and the extract was dried with magnesium sulfate. The solvent was distilled off and the residue was then purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (536.0 mg) as a white solid.

後処理

  1. customAfter the reaction
  2. distillationthe solvent was distilled off
  3. additionthe residue was then added with water
  4. extractionThe mixture was extracted with chloroform
  5. dry with materialthe extract was dried with magnesium sulfate
  6. distillationThe solvent was distilled off
  7. customthe residue was then purified through silica gel column chromatography (chloroform/ethyl acetate)

出典と根拠

ORDレコード
ord-b0f959b033fe402fb177dfd4d43fece4
出典データセット
uspto-grants-2007_02
特許番号
US07176227B2

関連ノート

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