反応式
C1(=O)[N:5]([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]([CH2:25][CH2:26][CH3:27])[CH2:22][CH2:23][CH3:24])[CH:13]=3)[CH:8]=2)C(=O)C2=CC=CC=C12>CN.CO>[NH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]([CH2:25][CH2:26][CH3:27])[CH2:22][CH2:23][CH3:24])[CH:13]=2)[CH:8]=1参加物
3
実験手順
The compound (75.0 mg) obtained in Example 124-3 was dissolved in a 40% methylamine/methanol solution (2.0 ml) and stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off and then the residue was added with a 1 mol/l sodium hydroxide aqueous solution and stirred. The solution was subjected to extraction with chloroform and the extract was then washed with saturated saline solution. Subsequently, the organic layer was dried with anhydrous sodium sulfate and the solvent was then distilled off, thereby obtaining the subject compound (67.5 mg) as a colorless oily substance.
後処理
- customAfter completion of the reaction
- distillationthe solvent was distilled off
- additionthe residue was added with a 1 mol/l sodium hydroxide aqueous solution
- stirringstirred
- extractionThe solution was subjected to extraction with chloroform
- washthe extract was then washed with saturated saline solution
- dry with materialSubsequently, the organic layer was dried with anhydrous sodium sulfate
- distillationthe solvent was then distilled off
出典と根拠
- ORDレコード
- ord-06f285c9b51643fe93d59be419362a9b
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07176227B2
関連ノート
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