1,2-Dichloroethane → 4-(benzyloxy)-N-propylbutanamide

関与物質

役割	名称	HCID	仕込み量
反応物	1,2-Dichloroethane	HCID 11	—
反応物	Propylamine	HCID 7852	—
反応物	4-Methylmorpholine	HCID 7972	—
反応物	1-Hydroxybenzotriazole	HCID 75771	—
反応物	4-(Benzyloxy)butanoic acid	HCID 562201	—
溶媒	Dimethylformamide	HCID 6228	—
溶媒	Ethyl Acetate	HCID 8857	—
生成物	4-(benzyloxy)-N-propylbutanamide	HCID 21085924	79.8%

反応手順

A mixture of 4-benzyloxybutyric acid (2.69 g, 13.8 mmol), propylamine (0.82 g, 13.8 mmol), HOBt (2.05 g, 15.2 mmol), N-methylmorpholine (1.68 g, 16.6 mmol) and EDC (2.91 g, 15.2 mmol) in DMF (6 mL) is stirred at 20–25 degrees C. for 18 hours. The mixture is diluted with ethyl acetate (40 mL) and washed with water (10 mL), hydrochloric acid (1 N, 10 mL), saturated sodium bicarbonate (10 mL), and saline (10 mL). The organic phase is separated, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to provide 4-(benzyloxy)-N-propylbutanamide (2.59 g), APCI-MS (m/z) [M+H]+=236.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07176242B2
出典データセット	uspto-grants-2007_02
ORD ID	ord-357cc62f1c2b4656a9d9f6c815385651
出典メモ	uspto-grants-2007_02