Trimethylsilyldiazomethane → Methyl 3-bromo-5-(hydroxymethyl)benzoate

HRID 348894

反応式

HRID 348894 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH2:11][OH:12])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH3:13][Si](C=[N+]=[N-])(C)C>CO.C1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH2:11][OH:12])[CH:10]=1)[C:5]([O:7][CH3:13])=[O:6]

参加物

4

反応物 2

HCID 167693TrimethylsilyldiazomethaneHCID 81671273-Bromo-5-(hydroxymethyl)benzoic acid

生成物 1

HCID 11356988Methyl 3-bromo-5-(hydroxymethyl)benzoate

試薬・触媒・溶媒 1

HCID 21927730Benzene methanol溶媒

実験手順

To 3-bromo-5-(hydroxymethyl)benzoic acid (7.0 g, 30 mmol) in 20% methanol/benzene (100 mL) is added trimethylsilyldiazomethane (2M in hexanes), and the reaction is stirred 16 h. The reaction is concentrated under reduced pressure to afford the title compound. ESI MS m/z 244.0 [M+H]+.

後処理

  1. concentrationThe reaction is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-2db7ca275b6a4534b129f756e372e808
出典データセット
uspto-grants-2007_02
特許番号
US07176242B2

関連ノート

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