関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Benzenepropanoic acid, 4-nitro-beta-oxo-, ethyl ester | HCID 13281 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Acetic acid, (p-aminobenzoyl)-, ethyl ester (6CI,7CI) | HCID 3045879 | 83.1% |
反応手順
Into a mixture comprising 224 g of reduced iron, 13.4 g of ammonium chloride, 1 liter of isopropyl alcohol and 0.2 liter of water was added 237 g of ethyl p-nitrobenzoylacetate in small portions at a temperature between 50° C. and 70° C. with caution against heat generation. The mixture was allowed to react at 70° C. for 1 hour, followed by filtration. To the filtrate was added 1 liter of water, and crystals precipitated upon cooling to 5° C. were separated by filtration to obtain 172 g of ethyl p-aminobenzoylacetate as yellow crystals having a melting point of 82° to 84° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04764458 |
|---|
| 出典データセット | uspto-grants-1988_08 |
|---|
| ORD ID | ord-70063811dc024232a0f27156d70ecbb3 |
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| 出典メモ | uspto-grants-1988_08 |
|---|
