Propanoyl bromide, 2-bromo- → 6-(2-Bromopropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone

HRID 34902

反応式

HRID 34902 の反応式
[Br:1][CH:2]([CH3:6])[C:3](Br)=[O:4].[CH3:7][N:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][C:9]1=[O:18].[Cl-].[Al+3].[Cl-].[Cl-]>C(=S)=S>[Br:1][CH:2]([CH3:6])[C:3]([C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:18])[N:8]([CH3:7])[CH2:17]2)=[O:4]

参加物

5

反応物 3

HCID 79047Propanoyl bromide, 2-bromo-HCID 38465583,4-Dihydro-3-methyl-2(1H)-quinazolinoneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 138271666-(2-Bromopropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone

試薬・触媒・溶媒 1

HCID 6348Carbon Disulfide溶媒

実験手順

2-Bromopropionyl bromide (71.02 g) is added dropwise to a stirred mixture of 3,4-dihydro-3-methyl-2(1H)quinazolinone (26.75 g) and anhydrous aluminum chloride (54.98 g) in carbon disulfide (350 ml). The reaction mixture is stirred under reflux for 5 hrs., the carbon disulfide decanted, and the residue treated with HCl (6N). The resulting solid is filtered, and washed with water and dried in vacuo to obtain 6-(2-bromopropionyl)-3,4,dihydro-3-methyl-2(1H)-quinazolinone which is used in the next step.

後処理

  1. temperatureunder reflux for 5 hrs
  2. custom, the carbon disulfide decanted
  3. additionthe residue treated with HCl (6N)
  4. filtrationThe resulting solid is filtered
  5. washwashed with water
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-b3ac7eeee5c14cba98b5023f718d0974
出典データセット
uspto-grants-1988_08
特許番号
US04764512

関連ノート

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