p-Toluenesulfonic acid monohydrate → HCID 21086214、化合物

HRID 349037ノート

反応式

HRID 349037 の反応式
N[C:2]1[CH:3]=[CH:4][C:5]([OH:17])([C:13]([O:15][CH3:16])=[O:14])[CH2:6][C:7]=1[C:8](=[O:12])[CH2:9][CH2:10][CH3:11].O.C1(C)C=CC(S(O)(=O)=[O:26])=CC=1>O.O1CCCC1>[C:8]([CH:7]1[CH2:6][C:5]([OH:17])([C:13]([O:15][CH3:16])=[O:14])[CH:4]=[CH:3][C:2]1=[O:26])(=[O:12])[CH2:9][CH2:10][CH3:11]

参加物

4

反応物 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 21086195Methyl 4-amino-5-butyryl-1-hydroxycyclohexa-2,4-diene-1-carboxylate

生成物 1

HCID 21086214HCID 21086214、化合物

試薬・触媒・溶媒 1

HCID 21881883Oxolane--water (1/1)溶媒

実験手順

To a stirred solution of methyl 4-amino-5-butyryl-1-hydroxycyclohexa-2,4-diene-1-carboxylate (1.25 g, 5.2 mmol) in a 1:1 mixture of water/tetrahydrofuran (10 mL) was added p-toluenesulfonic acid monohydrate (1.1 g, 5.8 mmol). The reaction mixture was stirred for 18 h and then partitioned between dichloromethane and water. The organic layer was dried (sodium sulfate), filtered, and concentrated under reduced pressure to afford methyl 5-butyryl-1-hydroxy-4-oxocyclohex-2-ene-1-carboxylate which was used without further purification or characterization.

後処理

  1. custompartitioned between dichloromethane and water
  2. dry with materialThe organic layer was dried (sodium sulfate)
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-5e3310a5e374457c89ce790e195e4e3b
出典データセット
uspto-grants-2007_02
特許番号
US07176242B2

反応ノート

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