7-Bromo-1-Chloroisoquinoline → 7-bromo-2-(N-propylamino)isoquinoline

HRID 349046

反応式

HRID 349046 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2Cl)=[CH:4][CH:3]=1>C(N)CC>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]([NH:8][CH2:7][CH2:6][CH3:5])[CH2:9]2)=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 65020247-Bromo-1-Chloroisoquinoline

生成物 1

HCID 210859967-bromo-2-(N-propylamino)isoquinoline

試薬・触媒・溶媒 1

HCID 7852Propylamine溶媒

実験手順

A solution of 7-bromo-1-chloroisoquinoline in propylamine (15.0 mL) was heated at 70° C. in a sealed tube overnight. The reaction mixture was concentrated under reduced pressure, then dissolved in chloroform and washed with saturated sodium bicarbonate, saturated sodium chloride, dried (sodium sulfate), filtered, and concentrated under reduced pressure to yield 7-bromo-2-(N-propylamino)isoquinoline (820 mg): ESI MS m/z 266 [M+H]+

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. dissolutiondissolved in chloroform
  3. washwashed with saturated sodium bicarbonate, saturated sodium chloride
  4. dry with materialdried (sodium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d2c51219b1f84eae9fe9663e207d0dd8
出典データセット
uspto-grants-2007_02
特許番号
US07176242B2

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